International Journal of applied mathematics and computer science

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Paper details

Number 3 - September 2003
Volume 13 - 2003

Population genetics models for the statistics of DNA samples under different demographic scenarios - Maximum likelihood versus approximate methods

Andrzej Polański, Marek Kimmel

Abstract
The paper reviews the basic mathematical methodology of modeling neutral genetic evolution, including the statistics of the Fisher-Wright process, models of mutation and the coalescence method under various demographic scenarios. The basic approach is the use of maximum likelihood techniques. However, due to computational problems, intuitive or approximate methods are also of great importance.

Keywords
DNA samples, demography, coalescence